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05/18/2016

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Steve Hawkins

Hmm: Where is the pre 1960 control microbiome?

:/

Carlos Rodriguez

Sublethal concentrations of antibiotics have been implicated in triggering oxidative stress which may cause mutations leading to altered targets of antimicrobial drugs by inducing the SOS response (low doses of antibiotics serving as mutagenic agents): "Kohanski MA, DePristo MA, Collins JJ. Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. Mol Cell. 2010 Feb 12;37(3):311-20". Could this be inconspicuously happening with triclosan?

In murine models (which may not necessarily correlate with humans) triclosan has been associated with liver tumors: "Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17200-5".

Dave B

Did I miss something?
This article published same day seems to be saying the opposite?
http://oregonstate.edu/ua/ncs/archives/2016/may/common-antimicrobial-agent-rapidly-disrupts-gut-bacteria

mBiosphere

You're right that the PLOS One report released around the same time came to a different conclusion. Different animal models, drug concentration + administration, and bacterial diversity measurements can result in two scientists addressing the same question arriving at different conclusions. This is one reason repeated studies are important!

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